The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients
Melanie K. Schoutteten,
Lucas Lindeboom,
Hélène De Cannière,
Zoë Pieters,
Liesbeth Bruckers,
Astrid D. H. Brys,
Patrick van der Heijden,
Bart De Moor,
Jacques Peeters,
Chris Van Hoof,
Willemijn Groenendaal,
Jeroen P. Kooman,
Pieter M. Vandervoort
Affiliations
Melanie K. Schoutteten
Limburg Clinical Research Center/Mobile Health Unit, Faculty of Biomedical and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium
Lucas Lindeboom
Department of Health Research, imec the Netherlands/Holst Centre, High Tech Campus 31, 5656 AE Eindhoven, The Netherlands
Hélène De Cannière
Limburg Clinical Research Center/Mobile Health Unit, Faculty of Biomedical and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium
Zoë Pieters
Data Science Institute, Hasselt University, 3500 Hasselt, Belgium
Liesbeth Bruckers
Data Science Institute, Hasselt University, 3500 Hasselt, Belgium
Astrid D. H. Brys
Division of Geriatrics, Department of Internal Medicine, Maastricht University Medical Centre+, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Patrick van der Heijden
Department of Health Research, imec the Netherlands/Holst Centre, High Tech Campus 31, 5656 AE Eindhoven, The Netherlands
Bart De Moor
Limburg Clinical Research Center/Mobile Health Unit, Faculty of Biomedical and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium
Jacques Peeters
Department of Nephrology, Ziekenhuis Oost Limburg, Synaps Park 1, 3600 Genk, Belgium
Chris Van Hoof
Imec Belgium, Kapeldreef 75, 3001 Leuven, Belgium
Willemijn Groenendaal
Department of Health Research, imec the Netherlands/Holst Centre, High Tech Campus 31, 5656 AE Eindhoven, The Netherlands
Jeroen P. Kooman
Division of Nephrology, Department of Internal Medicine, Maastricht University Medical Centre+, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
Pieter M. Vandervoort
Limburg Clinical Research Center/Mobile Health Unit, Faculty of Biomedical and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium
Repeated single-point measurements of thoracic bioimpedance at a single (low) frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern of the bioimpedance signal, and multi-frequency measurements may add in-depth information on the distribution between intra- and extracellular fluid. This study aimed to investigate the feasibility of semi-continuous multi-frequency thoracic bioimpedance measurements by a wearable device in hemodialysis patients. Therefore, thoracic bioimpedance was recorded semi-continuously (i.e., every ten minutes) at nine frequencies (8–160 kHz) in 68 patients during two consecutive hemodialysis sessions, complemented by a single-point measurement at home in-between both sessions. On average, the resistance signals increased during both hemodialysis sessions and decreased during the interdialytic interval. The increase during dialysis was larger at 8 kHz (∆ 32.6 Ω during session 1 and ∆ 10 Ω during session 2), compared to 160 kHz (∆ 29.5 Ω during session 1 and ∆ 5.1 Ω during session 2). Whereas the resistance at 8 kHz showed a linear time pattern, the evolution of the resistance at 160 kHz was significantly different (p ith a multi-frequency current is a major step forward in the understanding of fluid dynamics in hemodialysis patients. This study paves the road towards remote fluid monitoring.
