Nature Communications (Mar 2023)
Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
- Fangyuan Zhang,
- Fei Qiu,
- Junlan Zeng,
- Zhichao Xu,
- Yueli Tang,
- Tengfei Zhao,
- Yuqin Gou,
- Fei Su,
- Shiyi Wang,
- Xiuli Sun,
- Zheyong Xue,
- Weixing Wang,
- Chunxian Yang,
- Lingjiang Zeng,
- Xiaozhong Lan,
- Min Chen,
- Junhui Zhou,
- Zhihua Liao
Affiliations
- Fangyuan Zhang
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Fei Qiu
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Junlan Zeng
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Zhichao Xu
- Heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization, Northeast Forestry University
- Yueli Tang
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Tengfei Zhao
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Yuqin Gou
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Fei Su
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Shiyi Wang
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Xiuli Sun
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Zheyong Xue
- Heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization, Northeast Forestry University
- Weixing Wang
- College of Horticulture and Landscape Architecture, Southwest University
- Chunxian Yang
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Lingjiang Zeng
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- Xiaozhong Lan
- TAAHC-SWU Medicinal Plant Joint R&D Centre, Tibetan Collaborative Innovation Centre of Agricultural and Animal Husbandry Resources, Xizang Agricultural and Animal Husbandry College
- Min Chen
- College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Ministry of Education), Southwest University
- Junhui Zhou
- State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Zhihua Liao
- State Key Laboratory of Silkworm Genome Biology, School of Life Sciences, Southwest University
- DOI
- https://doi.org/10.1038/s41467-023-37133-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Tropane alkaloids (TAs) are synthesized by some species in Solanaceae. Here, the authors assemble the genomes of two representative TAs producing species, show that gene loss shapes uneven distribution of TAs in Solanaceae, and identify a cytochrome P450 gene catalyzing N-demethylation of hyoscyamine to generate norhyoscyamine.
