F1000Research (Jun 2018)

Spectrum of Pituitary disorders: A retrospective study from Basrah, Iraq [version 2; referees: 2 approved]

  • Abbas Ali Mansour,
  • Ali Hussain Ali Alhamza,
  • Ammar Mohammed Saeed Abdullah Almomin,
  • Ibrahim Abbood Zaboon,
  • Nassar Taha Yaseen Alibrahim,
  • Rudha Naser Hussein,
  • Muayad Baheer Kadhim,
  • Haider Ayad Yassin Alidrisi,
  • Hussein Ali Nwayyir,
  • Adel Gassab Mohammed,
  • Dheyaa Kadhim Al-Waeli,
  • Ibrahim Hani Hussein

DOI
https://doi.org/10.12688/f1000research.13632.2
Journal volume & issue
Vol. 7

Abstract

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Background: Pituitary disorders spectrum includes a wide variety of diseases.This study aimed at a comprehensive description of such disorders for patients from Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah (Southern Iraq). Methods: Retrospective data analysis of FDEMC for the period from January 2012 through June 2017. We included all patients with pituitary disorders who have MRI pituitary. Results: The pituitary disorders were more common among women. Those with macroadenoma were older than those with microadenoma with nearly equal gender prevalence of macroadenoma. Pituitary adenoma constituted the bulk of pituitary disorders in this registry (67.2%). Growth hormone secreting adenoma were the commonest adenoma seen in 41.0% followed by clinically non-functioning pituitary adenoma(NFPA)in 31.4% and prolactinoma in 26.9%. About 64.8% of pituitary adenoma was macroadenoma. Macroadenoma was seen in 73.4 % of growth hormone secreting adenoma, 61.2% in NFPA and 62.0% of prolactinoma (of them six were giant prolactinoma) Conclusion: Pituitary adenoma constituted the bulk of pituitary disorders in Basrah, growth hormone secreting adenoma is the commonest adenoma followed by NFPA and prolactinoma due to referral bias. A change in practice of pituitary adenoma treatment is needed.