Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Abstract

Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.

Keywords

• proteostasis
• dna damage response
• chemotherapy
• phosphorylation
• prognostic biomarker