Haematologica (Dec 2015)

Identification of novel microRNA signatures linked to acquired aplastic anemia

  • Kohei Hosokawa,
  • Pawel Muranski,
  • Xingmin Feng,
  • Keyvan Keyvanfar,
  • Danielle M. Townsley,
  • Bogdan Dumitriu,
  • Jichun Chen,
  • Sachiko Kajigaya,
  • James G. Taylor,
  • Christopher S. Hourigan,
  • A. John Barrett,
  • Neal S. Young

DOI
https://doi.org/10.3324/haematol.2015.126128
Journal volume & issue
Vol. 100, no. 12

Abstract

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Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated immune disease. Analysis of 84 microRNA expression levels in CD4+ and CD8+ T cells of patients with aplastic anemia revealed concurrent down-regulation of miR-126-3p, miR-145-5p, miR-223-3p, and miR-199a-5p (>3-fold change, P2-fold change, P