Haematologica
(Dec 2015)
Identification of novel microRNA signatures linked to acquired aplastic anemia
Kohei Hosokawa,
Pawel Muranski,
Xingmin Feng,
Keyvan Keyvanfar,
Danielle M. Townsley,
Bogdan Dumitriu,
Jichun Chen,
Sachiko Kajigaya,
James G. Taylor,
Christopher S. Hourigan,
A. John Barrett,
Neal S. Young
Affiliations
Kohei Hosokawa
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Pawel Muranski
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Xingmin Feng
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Keyvan Keyvanfar
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Danielle M. Townsley
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Bogdan Dumitriu
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Jichun Chen
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Sachiko Kajigaya
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
James G. Taylor
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Christopher S. Hourigan
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
A. John Barrett
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
Neal S. Young
Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA
DOI
https://doi.org/10.3324/haematol.2015.126128
Journal volume & issue
Vol. 100,
no. 12
Abstract
Read online
Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated immune disease. Analysis of 84 microRNA expression levels in CD4+ and CD8+ T cells of patients with aplastic anemia revealed concurrent down-regulation of miR-126-3p, miR-145-5p, miR-223-3p, and miR-199a-5p (>3-fold change, P2-fold change, P
Published in Haematologica
ISSN
0390-6078 (Print)
1592-8721 (Online)
Publisher
Ferrata Storti Foundation
Country of publisher
Italy
LCC subjects
Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website
http://www.haematologica.org
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