Bone Reformative Capability of Nano-chitosan in Rabbits

Abstract

Aims: To evaluate the ability of natural biomaterial nano chitosan for osteogenic regeneration in rabbit animal models. Materials and methods: Eighteen male domestic rabbits were used in the study the formation of two bony defects was created in the rabbit's femur, one filled with nano chitosan material, and the other defect was left empty as a control. Densitometry and histomorphometric analysis were measured at, 7 days, 14 days, and 28 days which was used as a parameter. Results: The nano chitosan showed lesser radio-opacity than the control with a positive osteogenic effect due to the osteoinduction and osseointegration properties. Conclusions: This study supports that nano chitosan natural polymer may have better application prospects for bone repair and acceleration of the healing process.

Keywords

• nano chitosan bone substitutes
• natural biomaterial
• osteogenic regeneration