PLoS ONE (Jan 2022)

Longitudinal analyses and predictive factors of radiation-induced lung toxicity-related parameters after stereotactic radiotherapy for lung cancer

  • Takaya Yamamoto,
  • Yoshiyuki Katsuta,
  • Kiyokazu Sato,
  • Yoko Tsukita,
  • Rei Umezawa,
  • Noriyoshi Takahashi,
  • Yu Suzuki,
  • Kazuya Takeda,
  • Keita Kishida,
  • So Omata,
  • Eisaku Miyauchi,
  • Ryota Saito,
  • Noriyuki Kadoya,
  • Keiichi Jingu

Journal volume & issue
Vol. 17, no. 12

Abstract

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Background and purpose The purpose of this prospective study was to investigate changes in longitudinal parameters after stereotactic radiotherapy for lung cancer and to identify possible pretreatment factors related to radiation-induced lung toxicity and the decline in pulmonary function after radiotherapy. Materials and methods Protocol-specified examinations, including 4-D CT, laboratory tests, pulmonary function tests (PFTs) and body composition measurements, were performed before SRT and at 1 month, 4 months and 12 months after stereotactic radiotherapy. Longitudinal differences were tested by using repeated-measures analysis of variance. Correlations were examined by using the Pearson product-moment correlation coefficient (r). Results Sixteen patients were analyzed in this study. During a median follow-up period of 26.6 months, grade 1 and 2 lung toxicity occurred in 11 patients and 1 patient, respectively. The mean Hounsfield units (HU) and standard deviation (SD) of the whole lung, as well as sialylated carbohydrate antigen KL-6 (KL-6) and surfactant protein-D (SP-D), peaked at 4 months after radiotherapy (p = 0.11, pConclusions The results indicated that some parameters peaked at 4 months, but PFTs were the lowest at 12 months. Significant correlations between lung V5 Gy (cc) and changes in DLCO and DLCO/alveolar volume were observed.