Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Lu Zong; Hui Peng; Cheng Sun; Fenglei Li; Meijuan Zheng; Yongyan Chen; Haiming Wei; Rui Sun; Zhigang Tian

doi:10.1038/s41467-018-08096-8

Nature Communications (Jan 2019)

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Lu Zong,
Hui Peng,
Cheng Sun,
Fenglei Li,
Meijuan Zheng,
Yongyan Chen,
Haiming Wei,
Rui Sun,
Zhigang Tian

Affiliations

Lu Zong: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Hui Peng: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Cheng Sun: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Fenglei Li: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Meijuan Zheng: Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University
Yongyan Chen: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Haiming Wei: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Rui Sun: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Zhigang Tian: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-08096-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Chronic hepatitis B virus (HBV) infection is a risk factor for hepatocellular carcinoma (HCC) and is associated with immune tolerance to HBV. Here the authors show, in a transgenic mouse model, that rescuing T cells function via inhibition of co-inhibitory receptor TIGIT results in HCC development via supporting inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal