Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Jiaxuan Qin; Jiaxuan Qin; Jiaxuan Qin; Yufeng Yang; Yufeng Yang; Yufeng Yang; Xuan Zhuang; Xuan Zhuang; Xuan Zhuang; Jinchun Xing; Jinchun Xing; Jinchun Xing

doi:10.3389/fendo.2020.00002

Frontiers in Endocrinology (Jan 2020)

Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Jiaxuan Qin,
Jiaxuan Qin,
Jiaxuan Qin,
Yufeng Yang,
Yufeng Yang,
Yufeng Yang,
Xuan Zhuang,
Xuan Zhuang,
Xuan Zhuang,
Jinchun Xing,
Jinchun Xing,
Jinchun Xing

Affiliations

Jiaxuan Qin: Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
Jiaxuan Qin: Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China
Jiaxuan Qin: The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, China
Yufeng Yang: Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
Yufeng Yang: Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China
Yufeng Yang: The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xuan Zhuang: Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xuan Zhuang: Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China
Xuan Zhuang: The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, China
Jinchun Xing: Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China
Jinchun Xing: Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China
Jinchun Xing: The Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, The First Affiliated Hospital of Xiamen University, Xiamen, China

DOI: https://doi.org/10.3389/fendo.2020.00002
Journal volume & issue: Vol. 11

Abstract

Read online

Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis.Methods: Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs.Results: Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup.Conclusions: Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

About the journal

Abstract

Keywords