Cancers (Mar 2022)
Comparison of Active Surveillance to Stereotactic Radiosurgery for the Management of Patients with an Incidental Frontobasal Meningioma—A Sub-Analysis of the IMPASSE Study
- Abdurrahman I. Islim,
- Georgios Mantziaris,
- Stylianos Pikis,
- Ching-Jen Chen,
- Adomas Bunevicius,
- Selçuk Peker,
- Yavuz Samanci,
- Ahmed M. Nabeel,
- Wael A. Reda,
- Sameh R. Tawadros,
- Amr M. N. El-Shehaby,
- Khaled Abdelkarim,
- Reem M. Emad,
- Violaine Delabar,
- David Mathieu,
- Cheng-Chia Lee,
- Huai-Che Yang,
- Roman Liscak,
- Jaromir May,
- Roberto Martinez Alvarez,
- Nuria Martinez Moreno,
- Manjul Tripathi,
- Douglas Kondziolka,
- Herwin Speckter,
- Camilo Albert,
- Greg N. Bowden,
- Ronald J. Benveniste,
- Lawrence Dade Lunsford,
- Jason P. Sheehan,
- Michael D. Jenkinson
Affiliations
- Abdurrahman I. Islim
- Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK
- Georgios Mantziaris
- Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA
- Stylianos Pikis
- Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA
- Ching-Jen Chen
- Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA
- Adomas Bunevicius
- Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA
- Selçuk Peker
- Department of Neurosurgery, Koc University School of Medicine, Istanbul 34010, Turkey
- Yavuz Samanci
- Department of Neurosurgery, Koc University School of Medicine, Istanbul 34010, Turkey
- Ahmed M. Nabeel
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Wael A. Reda
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Sameh R. Tawadros
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Amr M. N. El-Shehaby
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Khaled Abdelkarim
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Reem M. Emad
- Gamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt
- Violaine Delabar
- Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
- David Mathieu
- Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
- Cheng-Chia Lee
- Department of Neurosurgery, School of Medicine, Neurological Institute, Taipei Veteran General Hospital, Taipei City 11217, Taiwan
- Huai-Che Yang
- Department of Neurosurgery, School of Medicine, Neurological Institute, Taipei Veteran General Hospital, Taipei City 11217, Taiwan
- Roman Liscak
- Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, 150 00 Prague, Czech Republic
- Jaromir May
- Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, 150 00 Prague, Czech Republic
- Roberto Martinez Alvarez
- Department of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain
- Nuria Martinez Moreno
- Department of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain
- Manjul Tripathi
- Department of Neurosurgery and Radiotherapy, Nehru Hospital Sector 12, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Punjab, India
- Douglas Kondziolka
- Department of Neurosurgery, New York University, New York, NY 10016, USA
- Herwin Speckter
- Department of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo 10514, Dominican Republic
- Camilo Albert
- Department of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo 10514, Dominican Republic
- Greg N. Bowden
- Department of Neurosurgery, 2D1.02 Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2B7, Canada
- Ronald J. Benveniste
- Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
- Lawrence Dade Lunsford
- Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15260, USA
- Jason P. Sheehan
- Department of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA
- Michael D. Jenkinson
- Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK
- DOI
- https://doi.org/10.3390/cancers14051300
- Journal volume & issue
-
Vol. 14,
no. 5
p. 1300
Abstract
Meningioma is a common incidental finding, and clinical course varies based on anatomical location. The aim of this sub-analysis of the IMPASSE study was to compare the outcomes of patients with an incidental frontobasal meningioma who underwent active surveillance to those who underwent upfront stereotactic radiosurgery (SRS). Data were retrospectively collected from 14 centres. The active surveillance (n = 28) and SRS (n = 84) cohorts were compared unmatched and matched for age, sex, and duration of follow-up (n = 25 each). The study endpoints included tumor progression, new symptom development, and need for further intervention. Tumor progression occurred in 52.0% and 0% of the matched active surveillance and SRS cohorts, respectively (p p = 0.329). No patients in the matched cohorts developed symptoms attributable to treatment. Three patients managed with active surveillance (10.7%, unmatched; 12.0%, matched) underwent an intervention for tumor growth with no persistent side effects after treatment. No patients subject to SRS underwent further treatment. Active monitoring and SRS confer a similarly low risk of symptom development. Upfront treatment with SRS improves imaging-defined tumor control. Active surveillance and SRS are acceptable treatment options for incidental frontobasal meningioma.
Keywords
