Two New Cyanogenic Glucosides from the Leaves of <em>Hydrangea macrophylla</em>

Abstract

Chemical investigation of the ethanol extract of the aerial parts of <em>Hydrangea macrophylla </em>collected in the Sichuan Province of China resulted in the isolation of two new cyanogenic glucosides. Their structures were elucidated as [(2<em>R</em>)-2-(<em>b</em>-D-glucopyranosyloxy)-2-(3,4-dimethoxy-phenyl)] acetonitrile (<strong>1</strong>) and {(2<em>R</em>)-2-[<em>a</em>-D-glucopyranosyl(1®6)<em>b</em>-D-glucopyranosyloxy]-2-(3-hydroxy-4-methoxy-phenyl)}acetonitrile (<strong>2</strong>) on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies.

Keywords

• &lt;em&gt;Hydrangea macrophylla&lt;/em&gt;
• Saxifragaceae
• cyanogenic glucoside