Nature Communications (Mar 2023)
Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis
- Hong Sheng Quah,
- Elaine Yiqun Cao,
- Lisda Suteja,
- Constance H. Li,
- Hui Sun Leong,
- Fui Teen Chong,
- Shilpi Gupta,
- Camille Arcinas,
- John F. Ouyang,
- Vivian Ang,
- Teja Celhar,
- Yunqian Zhao,
- Hui Chen Tay,
- Jerry Chan,
- Takeshi Takahashi,
- Daniel S. W. Tan,
- Subhra K. Biswas,
- Owen J. L. Rackham,
- N. Gopalakrishna Iyer
Affiliations
- Hong Sheng Quah
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Elaine Yiqun Cao
- Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School
- Lisda Suteja
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Constance H. Li
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Hui Sun Leong
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Fui Teen Chong
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Shilpi Gupta
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Camille Arcinas
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- John F. Ouyang
- Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School
- Vivian Ang
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Teja Celhar
- HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Yunqian Zhao
- HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Hui Chen Tay
- HuNIT platform, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Jerry Chan
- Department of Reproductive Medicine, KK Women’s and Children’s Hospital
- Takeshi Takahashi
- Laboratory Animal Research Department, Central Institute for Experimental Animals (CIEA)
- Daniel S. W. Tan
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- Subhra K. Biswas
- Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR)
- Owen J. L. Rackham
- Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School
- N. Gopalakrishna Iyer
- Cancer Therapeutics Research Laboratory, National Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-023-37379-y
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
The molecular mechanisms underlying lymph-node metastasis in head and neck squamous-cell carcinoma remain to be investigated. Here, the authors perform single-cell RNA sequencing of cancer cells and CD8 + T cells and suggest potential mechanisms of immune evasion during early metastasis.
