The Utility of Iron Chelators in the Management of Inflammatory Disorders

C. Lehmann; S. Islam; S. Jarosch; J. Zhou; D. Hoskin; A. Greenshields; N. Al-Banna; N. Sharawy; A. Sczcesniak; M. Kelly; K. Wafa; W. Cheliak; B. Holbein

doi:10.1155/2015/516740

Mediators of Inflammation (Jan 2015)

The Utility of Iron Chelators in the Management of Inflammatory Disorders

C. Lehmann,
S. Islam,
S. Jarosch,
J. Zhou,
D. Hoskin,
A. Greenshields,
N. Al-Banna,
N. Sharawy,
A. Sczcesniak,
M. Kelly,
K. Wafa,
W. Cheliak,
B. Holbein

Affiliations

C. Lehmann: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
S. Islam: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
S. Jarosch: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
J. Zhou: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
D. Hoskin: Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 1X5, Canada
A. Greenshields: Department of Pathology, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
N. Al-Banna: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
N. Sharawy: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
A. Sczcesniak: Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
M. Kelly: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
K. Wafa: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, B3H 1X5, Canada
W. Cheliak: Chelation Partners Inc., 1411 Oxford St., Halifax, NS, B3H 3Z1, Canada
B. Holbein: Chelation Partners Inc., 1411 Oxford St., Halifax, NS, B3H 3Z1, Canada

DOI: https://doi.org/10.1155/2015/516740
Journal volume & issue: Vol. 2015

Abstract

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Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

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