Diabetes, Metabolic Syndrome and Obesity (Aug 2023)
Examining the Links Between Physical Activity, Sitting Time, and Renal Function in T2DM Patients
Abstract
Xiaoyu Wang,1,* Ning Yan,2,* Ruiping Pan,3 Yuqi Dang,4 Liqun Wang5,6 1School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 3Department of Chinese Medicine, The Second People’s Hospital of Shizuishan, Shizuishan, People’s Republic of China; 4Department of Endocrinology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, People’s Republic of China; 5Department of Epidemiology and Statistics, School of Public Health at Ningxia Medical University, Yinchuan, People’s Republic of China; 6Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liqun Wang, Department of Epidemiology and Statistics, School of Public Health at Ningxia Medical University, Yinchuan, People’s Republic of China, Tel +86 13649513216, Email [email protected]: Sitting time and physical activity are related to renal function among type 2 diabetes mellitus (T2DM); however, the mechanism of how it contributes to renal function is not well understood. The current study attempts to explore the relationship between sitting time and renal function among T2DM patients, with a particular focus on the mediating role of physical activity.Methods: This research uses the data of 1761 Chinese T2DM patients from Ningxia Province. Sitting time and physical activity were obtained during a face-to-face survey, and renal function was assessed by the estimated glomerular filtration rate (eGFR). The bootstrap method is used to test the mediating effect.Results: The research found that sitting time was negatively associated with eGFR and physical activity after controlling for covariates. Physical activity was positively associated with eGFR. Physical activity has mediated the relationship between sitting time and eGFR among T2DM patients (explaining 16.1% of the total variance).Conclusion: The present findings suggest that sitting time negatively affects eGFR among T2DM patients and provides new evidence that physical activity could attenuate the association between sitting time and eGFR. Hence, intervention strategies focusing on sitting time and physical activity should be paid more attention in the future.Keywords: sitting time, physical activity, eGFR, mediating effect, T2DM patients
