The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients

Yan E; Qiwen Deng; Guomei Shi; Zhongyuan Li; Chengfang Liu; Siyu Wang; Huiwen Lian; Haiming Cao; Xiaohao Zhang; Yingdong Zhang; Pengyu Gong; Teng Jiang

doi:10.3390/brainsci12111580

Brain Sciences (Nov 2022)

The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients

Yan E,
Qiwen Deng,
Guomei Shi,
Zhongyuan Li,
Chengfang Liu,
Siyu Wang,
Huiwen Lian,
Haiming Cao,
Xiaohao Zhang,
Yingdong Zhang,
Pengyu Gong,
Teng Jiang

Affiliations

Yan E: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Qiwen Deng: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Guomei Shi: Department of Neurology, Taixing People’s Hospital, Taixing 225400, China
Zhongyuan Li: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Chengfang Liu: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Siyu Wang: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Huiwen Lian: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Haiming Cao: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Xiaohao Zhang: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Yingdong Zhang: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Pengyu Gong: Department of Neurology, The Affiliated Hospital of Nantong University, Nantong 226000, China
Teng Jiang: Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

DOI: https://doi.org/10.3390/brainsci12111580
Journal volume & issue: Vol. 12, no. 11
p. 1580

Abstract

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Objective: This study aimed to investigate the association between high-mobility-group box 1 (HMGB1) and stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients. Methods: AIS patients were enrolled in two centers. The serum samples were collected within the first 24 h after admission, and HMGB1 levels were measured by enzyme-linked immunosorbent assay. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) of SAP for HMGB1 concentrations. Restricted cubic splines (RCS) were performed to explore the shapes of the association between HMGB1 concentrations and SAP. Results: From January 2022 to May 2022, a total of 420 AIS patients were enrolled. Ninety-six (22.9%) patients develop SAP. The levels of HMGB1 in the SAP group were higher than those in the non-SAP group (p p for linear trend = 0.008) Conclusions: HMGB1 might be able to act as a potential biomarker of SAP in AIS patients.

Published in Brain Sciences

ISSN: 2076-3425 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.mdpi.com/journal/brainsci/

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