The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration

Xue Chen; Joe Necus; Luis R. Peraza; Ramtin Mehraram; Yanjiang Wang; John T. O’Brien; Andrew Blamire; Marcus Kaiser; John-Paul Taylor

doi:10.1038/s42003-021-02497-0

Communications Biology (Aug 2021)

The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration

Xue Chen,
Joe Necus,
Luis R. Peraza,
Ramtin Mehraram,
Yanjiang Wang,
John T. O’Brien,
Andrew Blamire,
Marcus Kaiser,
John-Paul Taylor

Affiliations

Xue Chen: College of Control Science and Engineering, China University of Petroleum (East China)
Joe Necus: Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing, Newcastle University
Luis R. Peraza: Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality
Ramtin Mehraram: Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing, Newcastle University
Yanjiang Wang: College of Control Science and Engineering, China University of Petroleum (East China)
John T. O’Brien: Department of Psychiatry, University of Cambridge School of Medicine
Andrew Blamire: Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality
Marcus Kaiser: Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing, Newcastle University
John-Paul Taylor: Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality

DOI: https://doi.org/10.1038/s42003-021-02497-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 16

Abstract

Read online

Chen at al used fMRI to study the brain connectivity in two ageing cohorts and a mixed cohort of patients with neurodegenerative diseases. They demonstrated that with ageing the brain moves towards a more segregated modular structure, however this is disrupted by neurodegenerative diseases.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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