DESIGN AND EVALUATION OF A METRONIDAZOLE CENTRAL CORE MATRIX TABLET

Abstract

In this paper, a study of different concentration of HPMC K 15 M exerts influenceon the drug release process from a new controlled drug delivery system has been realizedin order to obtain a constant release rate during a prolonged period of time, for aprogrammed drug release. The drug release profiles obtained for the different batcheshave shown an interesting relationship between the particle size of the channeling agentused and the length of different operational periods.

Keywords

• Matrix
• Metronidazole
• Controlled drug delivery system
• Tablets