Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry

B. Kalderon; V. Sheena; S. Shachrur; R. Hertz; J. Bar-Tana

Journal of Lipid Research (Jul 2002)

Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry

B. Kalderon,
V. Sheena,
S. Shachrur,
R. Hertz,
J. Bar-Tana

Affiliations

B. Kalderon: Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120
V. Sheena: Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120
S. Shachrur: Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120
R. Hertz: Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120
J. Bar-Tana: To whom correspondence should be addressed; Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120

Journal volume & issue: Vol. 43, no. 7
pp. 1125 – 1132

Abstract

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The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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