Nature Communications (Oct 2016)
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
- Tyler K. Ulland,
- Nidhi Jain,
- Emma E. Hornick,
- Eric I. Elliott,
- Gwendolyn M. Clay,
- Jeffrey J. Sadler,
- Kathleen A. M. Mills,
- Ann M. Janowski,
- A. Paige Davis Volk,
- Kai Wang,
- Kevin L. Legge,
- Lokesh Gakhar,
- Mohammed Bourdi,
- Polly J. Ferguson,
- Mary E. Wilson,
- Suzanne L. Cassel,
- Fayyaz S. Sutterwala
Affiliations
- Tyler K. Ulland
- Inflammation Program, University of Iowa Carver College of Medicine
- Nidhi Jain
- Inflammation Program, University of Iowa Carver College of Medicine
- Emma E. Hornick
- Inflammation Program, University of Iowa Carver College of Medicine
- Eric I. Elliott
- Inflammation Program, University of Iowa Carver College of Medicine
- Gwendolyn M. Clay
- Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa Carver College of Medicine
- Jeffrey J. Sadler
- Inflammation Program, University of Iowa Carver College of Medicine
- Kathleen A. M. Mills
- Inflammation Program, University of Iowa Carver College of Medicine
- Ann M. Janowski
- Inflammation Program, University of Iowa Carver College of Medicine
- A. Paige Davis Volk
- Inflammation Program, University of Iowa Carver College of Medicine
- Kai Wang
- Department of Biostatistics, University of Iowa College of Public Health
- Kevin L. Legge
- Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine
- Lokesh Gakhar
- Department of Biochemistry, University of Iowa Carver College of Medicine
- Mohammed Bourdi
- Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health
- Polly J. Ferguson
- Department of Pediatrics, University of Iowa Carver College of Medicine
- Mary E. Wilson
- Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa Carver College of Medicine
- Suzanne L. Cassel
- Inflammation Program, University of Iowa Carver College of Medicine
- Fayyaz S. Sutterwala
- Inflammation Program, University of Iowa Carver College of Medicine
- DOI
- https://doi.org/10.1038/ncomms13180
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The role of NLRP12 in immunity to bacterial infection is controversial as varied and contrasting results have been published using C57BL/6 mice. Here the authors shed light on this issue, showing that unlike C57BL/6N mice, C57BL/6J mice have a missense point mutation in NLRP12 that is associated with defective neutrophil recruitment.
