Advances in the study of neurovascular coupling in bone repair

Abstract

Bone repair is a complex physiological process. The nerves within the bone can regulate bone tissue regeneration through the secretion of bioactive factors and interactions with cells within the bone. Recent studies have sought to leverage the principles of neurovascular coupling in the creation of bioactive materials, yielding promising results. This article reviews nerves and vessels within the bone, the role of neural signals in bone repair, and potential mechanisms of neurovascular coupling in bone repair, expecting to provide a thorough understanding on the function of neurovascular coupling in bone repair as well as fresh perspectives on the scientific research and clinical treatment of bone repair strategies.

Keywords

• neurovascular coupling
• bone repair
• nerves within bone
• tissue engineering