Nature Communications (Nov 2022)
Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites
- David Guerrero,
- Hoa Thi My Vo,
- Chanthap Lon,
- Jennifer A. Bohl,
- Sreynik Nhik,
- Sophana Chea,
- Somnang Man,
- Sokunthea Sreng,
- Andrea R. Pacheco,
- Sokna Ly,
- Rathanak Sath,
- Sokchea Lay,
- Dorothée Missé,
- Rekol Huy,
- Rithea Leang,
- Hok Kry,
- Jesus G. Valenzuela,
- Fabiano Oliveira,
- Tineke Cantaert,
- Jessica E. Manning
Affiliations
- David Guerrero
- Institut Pasteur du Cambodge, Pasteur Network
- Hoa Thi My Vo
- Institut Pasteur du Cambodge, Pasteur Network
- Chanthap Lon
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jennifer A. Bohl
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sreynik Nhik
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sophana Chea
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Somnang Man
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sokunthea Sreng
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Andrea R. Pacheco
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sokna Ly
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Rathanak Sath
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sokchea Lay
- Institut Pasteur du Cambodge, Pasteur Network
- Dorothée Missé
- MIVEGEC, Univ. Montpellier, IRD, CNRS
- Rekol Huy
- National Center of Parasitology, Entomology, and Malaria Control
- Rithea Leang
- National Center of Parasitology, Entomology, and Malaria Control
- Hok Kry
- Kampong Speu Provincial District, Ministry of Health
- Jesus G. Valenzuela
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Fabiano Oliveira
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tineke Cantaert
- Institut Pasteur du Cambodge, Pasteur Network
- Jessica E. Manning
- International Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-34534-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Vector-borne pathogens are known to elicit immune response upon mosquito biting the host which is critically linked to the establishment of infection and pathogenesis of disease, yet the impact of the mosquito bite itself is not immunologically well-appreciated. Here the authors characterize the immune response to the mosquito vector Aedes aegypti in a controlled human in vivo challenge model and show the induction of a range of immune pathways and cell types.
