Nature Communications (Apr 2021)
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
- Jake W. Rhodes,
- Rachel A. Botting,
- Kirstie M. Bertram,
- Erica E. Vine,
- Hafsa Rana,
- Heeva Baharlou,
- Peter Vegh,
- Thomas R. O’Neil,
- Anneliese S. Ashhurst,
- James Fletcher,
- Grant P. Parnell,
- J. Dinny Graham,
- Najla Nasr,
- Jake J. K. Lim,
- Laith Barnouti,
- Peter Haertsch,
- Martijn P. Gosselink,
- Angelina Di Re,
- Faizur Reza,
- Grahame Ctercteko,
- Gregory J. Jenkins,
- Andrew J. Brooks,
- Ellis Patrick,
- Scott N. Byrne,
- Eric Hunter,
- Muzlifah A. Haniffa,
- Anthony L. Cunningham,
- Andrew N. Harman
Affiliations
- Jake W. Rhodes
- Centre for Virus Research, The Westmead Institute for Medical Research
- Rachel A. Botting
- Centre for Virus Research, The Westmead Institute for Medical Research
- Kirstie M. Bertram
- Centre for Virus Research, The Westmead Institute for Medical Research
- Erica E. Vine
- Centre for Virus Research, The Westmead Institute for Medical Research
- Hafsa Rana
- Centre for Virus Research, The Westmead Institute for Medical Research
- Heeva Baharlou
- Centre for Virus Research, The Westmead Institute for Medical Research
- Peter Vegh
- Biosciences Institute, The University of Newcastle
- Thomas R. O’Neil
- Centre for Virus Research, The Westmead Institute for Medical Research
- Anneliese S. Ashhurst
- School of Medical Sciences, Faculty of Medicine and Health Sydney, The University of Sydney
- James Fletcher
- Biosciences Institute, The University of Newcastle
- Grant P. Parnell
- Centre for Virus Research, The Westmead Institute for Medical Research
- J. Dinny Graham
- Centre for Virus Research, The Westmead Institute for Medical Research
- Najla Nasr
- Centre for Virus Research, The Westmead Institute for Medical Research
- Jake J. K. Lim
- Dr Jake Lim PLC
- Laith Barnouti
- Australia Plastic Surgery
- Peter Haertsch
- Burns Unit, Concord Repatriation General Hospital
- Martijn P. Gosselink
- Centre for Virus Research, The Westmead Institute for Medical Research
- Angelina Di Re
- Centre for Virus Research, The Westmead Institute for Medical Research
- Faizur Reza
- Centre for Virus Research, The Westmead Institute for Medical Research
- Grahame Ctercteko
- Centre for Virus Research, The Westmead Institute for Medical Research
- Gregory J. Jenkins
- Department of Obstetrics and Gynaecology, Westmead Hospital
- Andrew J. Brooks
- Department of Urology, Westmead Hospital
- Ellis Patrick
- Centre for Virus Research, The Westmead Institute for Medical Research
- Scott N. Byrne
- Centre for Virus Research, The Westmead Institute for Medical Research
- Eric Hunter
- Emory Vaccine Centre
- Muzlifah A. Haniffa
- Biosciences Institute, The University of Newcastle
- Anthony L. Cunningham
- Centre for Virus Research, The Westmead Institute for Medical Research
- Andrew N. Harman
- Centre for Virus Research, The Westmead Institute for Medical Research
- DOI
- https://doi.org/10.1038/s41467-021-22375-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.
