Nature Communications (Apr 2021)

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

  • Jake W. Rhodes,
  • Rachel A. Botting,
  • Kirstie M. Bertram,
  • Erica E. Vine,
  • Hafsa Rana,
  • Heeva Baharlou,
  • Peter Vegh,
  • Thomas R. O’Neil,
  • Anneliese S. Ashhurst,
  • James Fletcher,
  • Grant P. Parnell,
  • J. Dinny Graham,
  • Najla Nasr,
  • Jake J. K. Lim,
  • Laith Barnouti,
  • Peter Haertsch,
  • Martijn P. Gosselink,
  • Angelina Di Re,
  • Faizur Reza,
  • Grahame Ctercteko,
  • Gregory J. Jenkins,
  • Andrew J. Brooks,
  • Ellis Patrick,
  • Scott N. Byrne,
  • Eric Hunter,
  • Muzlifah A. Haniffa,
  • Anthony L. Cunningham,
  • Andrew N. Harman

DOI
https://doi.org/10.1038/s41467-021-22375-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.