Serum Adiponectin in Type 2 Diabetic Women and Its Correlation with HbA1c and CRP

Abstract

Introduction & Objective: Adiponectin secretes by adipose tissue and play an important role in hyperglycemia and inflammatory mechanism. The objective of this study was to compare the levels of adiponectin, CRP and HbA1c in diabetic and healthy women and to determine the correlation coefficient between these factors in each study group. Materials & Methods: We designed a case-control study to assess baseline adiponectin concentrations in diabetic and healthy women. We used Spearman coefficient to determine correlation between adiponectin with ‍CRP, HbA1c. Results: After adjusting for age and BMI, adiponectin was lower in diabetic women (7.29 ± 1.42 µg/ml) compared to healthy women (10.29 ± 1.93 µg/ml) (P<0.01) and there was a negative correlation between adiponectin with ‍CRP and HbA1c. Conclusion: This study suggested the anti-diabeteic and anti-inflammatory properties of adiponectin.

Keywords

• adiponectin
• c-reactive protein
• diabetes mellitus
• hemoglobin a
• glycosylated