Altered dynamic effective connectivity of the default mode network in type 2 diabetes

Kun Xu; Kun Xu; Jun Wang; Jun Wang; Guangyao Liu; Guangyao Liu; Jiahao Yan; Jiahao Yan; Miao Chang; Miao Chang; Linzhen Jiang; Linzhen Jiang; Jing Zhang; Jing Zhang

doi:10.3389/fneur.2023.1324988

Frontiers in Neurology (Jan 2024)

Altered dynamic effective connectivity of the default mode network in type 2 diabetes

Kun Xu,
Kun Xu,
Jun Wang,
Jun Wang,
Guangyao Liu,
Guangyao Liu,
Jiahao Yan,
Jiahao Yan,
Miao Chang,
Miao Chang,
Linzhen Jiang,
Linzhen Jiang,
Jing Zhang,
Jing Zhang

Affiliations

Kun Xu: Second Clinical School, Lanzhou University, Lanzhou, China
Kun Xu: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Jun Wang: Second Clinical School, Lanzhou University, Lanzhou, China
Jun Wang: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Guangyao Liu: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Guangyao Liu: Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou University Second Hospital, Lanzhou, China
Jiahao Yan: Second Clinical School, Lanzhou University, Lanzhou, China
Jiahao Yan: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Miao Chang: Second Clinical School, Lanzhou University, Lanzhou, China
Miao Chang: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Linzhen Jiang: Second Clinical School, Lanzhou University, Lanzhou, China
Linzhen Jiang: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Jing Zhang: Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China
Jing Zhang: Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou University Second Hospital, Lanzhou, China

DOI: https://doi.org/10.3389/fneur.2023.1324988
Journal volume & issue: Vol. 14

Abstract

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IntroductionAltered functional connectivity of resting-state functional magnetic resonance imaging (rs-fMRI) within default mode network (DMN) regions has been verified to be closely associated with cognitive decline in patients with Type 2 diabetes mellitus (T2DM), but most studies neglected the fluctuations of brain activities—the dynamic effective connectivity (DEC) within DMN of T2DM is still unknown.MethodsFor the current investigation, 40 healthy controls (HC) and 36 T2DM patients have been recruited as participants. To examine the variation of DEC between T2DM and HC, we utilized the methodologies of independent components analysis (ICA) and multivariate granger causality analysis (mGCA).ResultsWe found altered DEC within DMN only show decrease in state 1. In addition, the causal information flow of diabetic patients major affected areas which are closely associated with food craving and metabolic regulation, and T2DM patients stayed longer in low activity level and exhibited decreased transition rate between states. Moreover, these changes related negatively with the MoCA scores and positively with HbA1C level.ConclusionOur study may offer a fresh perspective on brain dynamic activities to understand the mechanisms underlying T2DM-related cognitive deficits.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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