COVID-19 Vaccination and Serological Profile of a Brazilian University Population
Marina dos Santos Barreto,
Beatriz Soares da Silva,
Ronaldy Santana Santos,
Deise Maria Rego Rodrigues Silva,
Eloia Emanuelly Dias Silva,
Pedro Henrique Macedo Moura,
Jessiane Bispo de Souza,
Lucas Alves da Mota Santana,
Dennyson Leandro M. Fonseca,
Igor Salerno Filgueiras,
Adriana Gibara Guimarães,
Otavio Cabral-Marques,
Lena F. Schimke,
Lysandro Pinto Borges
Affiliations
Marina dos Santos Barreto
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Beatriz Soares da Silva
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Ronaldy Santana Santos
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Deise Maria Rego Rodrigues Silva
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Eloia Emanuelly Dias Silva
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Pedro Henrique Macedo Moura
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Jessiane Bispo de Souza
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Lucas Alves da Mota Santana
Graduate Program in Dentistry, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Dennyson Leandro M. Fonseca
Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of São Paulo (USP), São Paulo 05508-090, SP, Brazil
Igor Salerno Filgueiras
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil
Adriana Gibara Guimarães
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Otavio Cabral-Marques
Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of São Paulo (USP), São Paulo 05508-090, SP, Brazil
Lena F. Schimke
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil
Lysandro Pinto Borges
Department of Pharmacy, Federal University of Sergipe, São Cristóvão 49100-000, SE, Brazil
Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations.
