Медицинская иммунология (Jul 2014)

CONFORMATION CHANGES OF HUMAN SERUM γ–GLOBULIN IN THE PRESENCE OF ZINC IONS

  • S. B. Cheknev,
  • E. E. Babaeva,
  • U. A. Vorobieva,
  • E. A. Denisova

DOI
https://doi.org/10.15789/1563-0625-2005-4-375-380
Journal volume & issue
Vol. 7, no. 4
pp. 375 – 380

Abstract

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Abstract. Conformational changes of human serum γ–globulin during interaction with the zinc ions were studied in a solution. It has been shown that the presence of zinc in over its physiological concentrations led to increase in optical density across the whole spectrum of γ–globulin ultraviolet absorption. On the contrary, hypochromia in the spectrum was registered after interaction of the protein with zinc used in subphisiological concentrations. Possible role of divalent metal cations in changes in conformation of the blood serum γ–globulins, and thereby in regulation of their effector functions was discussed. (Med. Immunol., 2005, vol.7, № 4, pp. 375–380)

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