Serum amyloid A1 protein in the prediction of acute myocardial infarction

Abstract

Objective To explore the predictive value of serum amyloid A1 (SAA1) in acute myocardial infarction (AMI). Methods A total of 139 patients with AMI and 146 patients with non coronary atherosclerotic heart disease admitted to the China-Japan Union Hospital of Jilin University from September 2017 to April 2019 were selected as the research objects. Enzyme linked immunosorbent assay (ELISA) was used to determine the level of SAA1 in plasma. Logistic regression was used to analyze the independent influencing factors of AMI, and receiver operating characteristic (ROC) curve was used to analyze the value of SAA1 in the diagnosis of AMI. Results The level of SAA1 in the AMI group was lower than that in the control group [2.62 (2.08,3.21) ng/mL vs 5.18 (3.24,8.27) ng/mL, Z=10.169, P<0.05]. The decrease in SAA1 level was correlated with high-density lipoprotein cholesterol, white blood cell count, and neutrophils/lymphocytes. Multivariate logistic regression analysis showed that the decreased SAA1 level was an independent risk factor for AMI occurrence. The ROC curve indicated that the cut-off value of SAA1 for diagnosing AMI was 3.14 ng/mL, and the AUC was 0.847, and the sensitivity and specificity were 76.1% and 80.1%, respectively. Conclusion The plasma levels of SAA1 decrease in AMI patients, and SAA1 levels may serve as an independent predictor of AMI.

Keywords

• acute myocardial infarction
• serum amyloid a1
• white blood cell count
• high density lipoprotein cholesterol
• apolipoprotein a1
• biomarker