Genetic variations in PADI4 and CCR6: a comprehensive meta-analysis on rheumatoid arthritis susceptibility

Abstract

Abstract Background Rheumatoid arthritis is a long-term autoimmune condition that causes damage and inflammation to the joints. Genetic factors, including polymorphisms in the PADI4 and CCR6 genes, contribute significantly to RA susceptibility. Methods To find research on RA, PADI4, CCR6, gene polymorphisms, and SNPs, we performed a meta-analysis using PubMed, Scopus, Medline, Google Scholar, and EMBASE. Inclusion criteria comprised case–control studies providing genotypic data and allele frequencies. Review Manager 5.4 was used to conduct statistical analysis and evaluate odds ratios with 95% confidence intervals. Results Heterogeneity analyses of CCR6 rs3093024 showed no significant associations across genetic models: allele (OR = 0.69, 95% CI [0.36–1.32]), homozygous (OR = 2.18, 95%CI [0.58–8.22]), heterozygous (OR = 0.60, 95% CI [0.31–1.16]), dominant (OR = 1.60, 95% CI [0.64–3.95]), and recessive (OR = 1.79, 95% CI [0.75–4.27]). Similarly, PADI4 rs1748033 and rs2240340 showed insignificant associations across all genetic models. Conclusion This meta-analysis identifies a substantial relationship between CCR6 rs3093024 and RA susceptibility in Asian populations. However, heterogeneity analyses indicate inconsistent associations for PADI4 rs1748033 and rs2240340 across different populations and genetic models, suggesting varied genetic influences. Further large-scale studies are required to confirm these results and investigate the complex genetic and environmental interactions underlying RA pathogenesis.

Keywords

• Rheumatoid arthritis
• PADI4
• CCR6
• Gene polymorphism
• Meta-analysis