Nature Communications (Dec 2019)
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
- Christine Quach,
- Ying Song,
- Hongrui Guo,
- Shun Li,
- Hadi Maazi,
- Marshall Fung,
- Nathaniel Sands,
- Douglas O’Connell,
- Sara Restrepo-Vassalli,
- Billy Chai,
- Dali Nemecio,
- Vasu Punj,
- Omid Akbari,
- Gregory E. Idos,
- Shannon M. Mumenthaler,
- Nancy Wu,
- Sue Ellen Martin,
- Ashley Hagiya,
- James Hicks,
- Hengmin Cui,
- Chengyu Liang
Affiliations
- Christine Quach
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Ying Song
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Hongrui Guo
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Shun Li
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Hadi Maazi
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Marshall Fung
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Nathaniel Sands
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Douglas O’Connell
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Sara Restrepo-Vassalli
- USC Michelson Center for Convergent Bioscience, Bridge Institute, University of Southern California
- Billy Chai
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Dali Nemecio
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Vasu Punj
- Department of Medicine, University of Southern California
- Omid Akbari
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- Gregory E. Idos
- Norris Comprehensive Cancer Center, University of Southern California
- Shannon M. Mumenthaler
- Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California
- Nancy Wu
- Norris Comprehensive Cancer Center Transgenic/Knockout Rodent Core Facility, University of Southern California
- Sue Ellen Martin
- Department of Pathology, Keck School of Medicine, University of Southern California
- Ashley Hagiya
- Department of Pathology, Keck School of Medicine, University of Southern California
- James Hicks
- USC Michelson Center for Convergent Bioscience, Bridge Institute, University of Southern California
- Hengmin Cui
- College of Veterinary Medicine, Sichuan Agriculture University
- Chengyu Liang
- Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
- DOI
- https://doi.org/10.1038/s41467-019-13475-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
UVRAG is involved in autophagy, which loses its tumour suppressor functions when in its truncated form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein and show impaired autophagy, enhanced inflammation and β-catenin stabilisation, which promotes spontaneous tumorigenesis.
