Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Giulia Antoniali; Fabrizio Serra; Lisa Lirussi; Mikiei Tanaka; Chiara D’Ambrosio; Shiheng Zhang; Slobodanka Radovic; Emiliano Dalla; Yari Ciani; Andrea Scaloni; Mengxia Li; Silvano Piazza; Gianluca Tell

doi:10.1038/s41467-017-00842-8

Nature Communications (Oct 2017)

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Giulia Antoniali,
Fabrizio Serra,
Lisa Lirussi,
Mikiei Tanaka,
Chiara D’Ambrosio,
Shiheng Zhang,
Slobodanka Radovic,
Emiliano Dalla,
Yari Ciani,
Andrea Scaloni,
Mengxia Li,
Silvano Piazza,
Gianluca Tell

Affiliations

Giulia Antoniali: Department of Medicine, Laboratory of Molecular Biology and DNA repair, University of Udine
Fabrizio Serra: Department of Medicine, Laboratory of Molecular Biology and DNA repair, University of Udine
Lisa Lirussi: Department of Medicine, Laboratory of Molecular Biology and DNA repair, University of Udine
Mikiei Tanaka: Laboratory of Biochemistry, National Heart Lung and Blood Institute, National Institutes of Health
Chiara D’Ambrosio: Proteomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM) National Research Council (CNR) of Italy
Shiheng Zhang: Cancer Center of Daping Hospital, Third Military Medical University
Slobodanka Radovic: IGA Technology Services srl
Emiliano Dalla: Laboratorio Nazionale CIB, Area Science Park Padriciano
Yari Ciani: Laboratorio Nazionale CIB, Area Science Park Padriciano
Andrea Scaloni: Proteomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM) National Research Council (CNR) of Italy
Mengxia Li: Cancer Center of Daping Hospital, Third Military Medical University
Silvano Piazza: Laboratorio Nazionale CIB, Area Science Park Padriciano
Gianluca Tell: Department of Medicine, Laboratory of Molecular Biology and DNA repair, University of Udine

DOI: https://doi.org/10.1038/s41467-017-00842-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

Read online

APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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