No differences in IVF pregnancy outcomes following hysteroscopic polypectomy using a manual hysteroscopic tissue removal device versus conventional resection
Chen Wang,
Yangqin Peng,
Qinmei Wang,
Yu Dong,
Huimin Liu,
Yaoshan Yao,
Yuan Li,
Ge Lin,
Fei Gong,
J Preston Parry,
Nigel Pereira,
India Morgan,
Steven R. Lindheim,
Hui Chen
Affiliations
Chen Wang
Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University
Yangqin Peng
Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University
Qinmei Wang
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Yu Dong
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Huimin Liu
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Yaoshan Yao
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Yuan Li
Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA
Ge Lin
Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University
Fei Gong
Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University
J Preston Parry
University Mississippi Medical Center
Nigel Pereira
Mount Sinai Fertility
India Morgan
Department of Obstetrics & Gynecology, Baylor Scott & White Health
Steven R. Lindheim
Department of Obstetrics & Gynecology, Baylor Scott & White Health
Hui Chen
Gynecological Minimally Invasive Center, Reproductive & Genetic Hospital of Citic- Xiangya
Abstract Background To compare in-vitro fertilization and embryo transfer (IVF-ET) pregnancy outcomes following endometrial polypectomy using either a manual mechanical hysteroscopic tissue resection device (mHTR) or traditional mechanical resection with scissors or polyp graspers resection. Methods This retrospective study examined 189 infertile patients who had undergone polypectomy prior to IVF-ET at Reproductive and Genetic Hospital of CITIC-XIANGYA. Patients undergoing polypectomy using manual mHTR resection were compared to those having the procedure through traditional mechanical resection. The primary outcome was clinical pregnancy rate (CPR) following the first ET after hysteroscopic polypectomy. Secondary outcomes included miscarriage rates and the optimal time interval from polyp resection to ET. Results One-hundred eleven (58.7%) patients underwent polypectomy via manual mHTR while 78 (41.3%) patients underwent traditional mechanical resection for polypectomy. Following the first ET, the positive pregnancy rate (80.2% vs. 79.5%; p = 1.000), CPR (70.3% vs. 74.4%; p = 0.652), and MR (11.5% vs. 12.1%; p = 1.000) were similar between those undergoing mHTR and traditional mechanical resection. After stratifying by the number of menstrual cycles from procedure (after next menses; 2 to 3 menstrual cycles; and > 3 menstrual cycles later), there was no differences in CPR when comparing the time from polypectomy and resection type. Conclusion This study suggests no differences in IVF pregnancy outcomes following hysteroscopic polypectomy regardless of surgical type using manual mHTR or traditional mechanical resection and the timing from resection.
