Exploring synergistic effects of Achyranthes bidentata Blume and Paeonia lactiflora Pall. on hypertension with liver yang hyperactivity using the multidisciplinary integrative strategy
Yanyan Zhang,
Peimei Yan,
Yuhui He,
Shan Ren,
Dingxiao Wu,
Yingwanqi Wang,
Siyao Song,
Peng Lu,
Xue Li,
Guangwei Li,
Weiwei Jia,
Ying Lyu,
Haiying Dong,
Dan Xiao,
Lin Ding,
Song Lin,
Yan Lin
Affiliations
Yanyan Zhang
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Peimei Yan
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Yuhui He
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Shan Ren
Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Dingxiao Wu
Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Yingwanqi Wang
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Siyao Song
Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Peng Lu
Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Xue Li
Department of Physiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Guangwei Li
Department of Pathophysiology, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Weiwei Jia
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Ying Lyu
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China
Haiying Dong
Department of Clinical Pathology Diagnosis, Qiqihar Medical University, Qiqihar, 161006, China
Dan Xiao
School of Medicine and Health, Harbin Institute of Technology, Harbin, 150000, China
Lin Ding
Department of Scientific Research, Science and Technology Achievement Transformation Center, Qiqihar Medical University, Qiqihar, 161006, China
Song Lin
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China; Key Laboratory of Homology of Medicine and Food Resources and Metabolic Disease Prevention and Treatment of Heilongjiang Province, Qiqihar, Heilongjiang Province, 161006, China; Corresponding author. Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China.
Yan Lin
Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China; Key Laboratory of Homology of Medicine and Food Resources and Metabolic Disease Prevention and Treatment of Heilongjiang Province, Qiqihar, Heilongjiang Province, 161006, China; Corresponding author. Center of Scientific Research, School of Basic Medicine, Qiqihar Medical University, Qiqihar, 161006, China.
Traditional Chinese Medicine (TCM) formulations serve as a multi-component pharmacological combination therapy with various potential targets and have collected extensive knowledge regarding the in vivo efficacy of treating cardiovascular disorders in clinical practice for thousands of years. However, the obscurity of the chemicals and the molecular mechanisms are impediments to their continued growth and globalization. Therefore, new modern medications based on the combination of beneficial TCM components with precise clinical efficacy are required. The goal of this study was to find the best combination of Achyranthes bidentata Blume (AB) and Paeonia lactiflora Pall. (PL) for hypertension with liver yang hyperactivity (HLYH). The integrated research consisting of principal component analysis (PCA), metabolomics, microbiology, and weighted correlation network analysis (WGCNA) were used to find the optimal combination of AB-PL combinations and reveal the mechanism of action. The result showed AB-PL (2:3) had a substantial protective impact on HLYH, as shown by lower blood pressure, improved liver yang hyperactivity, reduced cardiac remodeling and malondialdehyde (MDA), and increased NO content. Furthermore, the essential elements for AB-PL reducing hypertension may be related to 135 metabolites and 23 microorganisms. In conclusion, our findings support the efficacy of herbal remedies in the treatment of hypertension and provide some pharmacological evidence for the ongoing development of novel modern Chinese drugs for cardiovascular disorders.
