The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase

Abstract

Genome instability is a hallmark of cancer cells. The joining of distant DNA double-strand ends (DSEs) ineluctably leads to genome rearrangements. We found that the cohesion complex maintains genome stability by repressing the joining of distant DSEs specifically in the S phase, i.e., the main phase producing one-ended DSEs.

Keywords

• cohesin
• double-strand break repair
• genome rearrangements
• nhej
• replication stress