PLoS ONE (Jan 2018)

Preservative effect of Chinese cabbage (Brassica rapa subsp. pekinensis) extract on their molecular docking, antioxidant and antimicrobial properties.

  • Momna Rubab,
  • Ramachandran Chellia,
  • Kandasamy Saravanakumar,
  • Suresh Mandava,
  • Imran Khan,
  • Charles Nkufi Tango,
  • Mohammad Shakhawat Hussain,
  • Eric Banan-Mwine Daliri,
  • Se-Hun Kim,
  • Sudha Rani Ramakrishnan,
  • Myeong-Hyeon Wang,
  • Jongkook Lee,
  • Joong-Ho Kwon,
  • Sangeeta Chandrashekar,
  • Deog-Hwan Oh

DOI
https://doi.org/10.1371/journal.pone.0203306
Journal volume & issue
Vol. 13, no. 10
p. e0203306

Abstract

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This study aimed at investigating the antimicrobial activity of different solvent extracts of Chinese cabbage Brassica rapa subsp. pekinensis (BRARP) and their antioxidant and cytotoxicity properties. Of the different solvents extracts, the chloroform extracts (CE) were significantly inhibited the bacterial pathogens at minimum inhibitory concentration (MIC) of 16.5 mg.mL-1. Biochemical analysis revealed that total phenol (62.6 ± 0.05 mg GAE.g-1) and flavonoids (27.6 ± 0.04 mg QE.g-1) were higher in the extracts of BRARP, which resulted in enhanced antioxidant activity in CE. A total of eight dominant compounds were detected in the potent antimicrobial extract from BRARP based on GC-MS analysis. The molecular interactions study revealed that, among the screened compounds the 1,2-benzenedicarboxylic acid and 2,3-dicyanopropionamide interacted with the active site of pathogenicity and survival related protein with lipopolysaccharide (LpxC) with higer binding energy. This work concluded that the 1, 2-Benzenedicarboxylic acid and 2, 3-Dicyanopropionamide from BRARP was reported to be good non-cytotoxic and antioxidant antimicrobials against bacterial pathogens.