Daring the Challenge and Thinking Big: The Value of Early Process R&D

Abstract

The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (

Keywords

• Chiral dienes
• Diels-alder
• Flow chemistry
• Organocatalysis
• Process safety
• Qbd