Purified regenerating retinal neurons reveal regulatory role of DNA methylation-mediated Na+/K+-ATPase in murine axon regeneration

Elias Rizk; Andy Madrid; Joyce Koueik; Dandan Sun; Krista Stewart; David Chen; Susan Luo; Felissa Hong; Ligia A. Papale; Nithya Hariharan; Reid S. Alisch; Bermans J. Iskandar

doi:10.1038/s42003-023-04463-4

Communications Biology (Jan 2023)

Purified regenerating retinal neurons reveal regulatory role of DNA methylation-mediated Na+/K+-ATPase in murine axon regeneration

Elias Rizk,
Andy Madrid,
Joyce Koueik,
Dandan Sun,
Krista Stewart,
David Chen,
Susan Luo,
Felissa Hong,
Ligia A. Papale,
Nithya Hariharan,
Reid S. Alisch,
Bermans J. Iskandar

Affiliations

Elias Rizk: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Andy Madrid: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Joyce Koueik: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Dandan Sun: Department of Neurology, University of Pittsburgh School of Medicine
Krista Stewart: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
David Chen: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Susan Luo: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Felissa Hong: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Ligia A. Papale: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Nithya Hariharan: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Reid S. Alisch: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health
Bermans J. Iskandar: Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health

DOI: https://doi.org/10.1038/s42003-023-04463-4
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

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FACS-based sorting of regenerating retinal ganglion cells, following optic nerve transection in the rat, reveals a regulatory role of Na + /K + -ATPase in axon regeneration that is mediated by DNA methylation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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