Local delivery of checkpoints antibodies

Abstract

Immune checkpoint inhibitors (ICI) based cancer immunotherapy has recently attracted considerable interest in the field of cancer therapy. The relevant immunotherapeutic agents do not directly attack the tumor, but boost the body's immune system to recognize and kill cancer cells. In this commentary, recent efforts utilizing immunoengineering for local delivery of these immune checkpoint antibodies are introduced. Future opportunities and challenges in this research theme are also commented.

Keywords

• biomaterials
• cancer immunotherapy
• drug delivery
• immune checkpoint inhibitors
• microneedle