Medicine Science (Mar 2020)

Changes in thiol/disulfide homeostasis in patients with chronic kidney disease

  • Ibrahim Solak,
  • Ibrahim Guney,
  • Seher Mercan,
  • Ozcan Erel,
  • Salim Neselioglu,
  • Cigdem Damla Cetinkaya,
  • Mehmet Ali Eryilmaz

DOI
https://doi.org/10.5455/medscience.2019.08.9168
Journal volume & issue
Vol. 9, no. 1
pp. 201 – 4

Abstract

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Thiol/disulfide homeostasis (TDH) is a new marker of oxidative stress. In this study, we would like to determine the changes in TDH in hemodialysis (HD) patients with chronic kidney disease (CKD). This cross-sectional study was conducted in the Nephrology Clinic of Konya Training and Research Hospital. A total of 197 individuals including 75 HD patients, 41 end stage renal disease (ESRD) patients (having stage 3-5 CKD but not receiving hemodialysis), and 81 healthy controls were enrolled in the study. Serum native thiol, total thiol, and disulfide levels were measured with a new method developed by Erel and Neselioglu. It was determined that there was a statistically significant difference in the mean age, body mass index (BMI), modification of diet in renal disease (MDRD), and creatinine level between the three groups (p [Med-Science 2020; 9(1.000): 201-4]

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