Lifestyle modification effects on antihypertensive quinapril effectiveness in patients with arterial hypertension and obesity

Abstract

Aim. To assess the effectiveness of non-pharmaceutical body weight (BW) reduction and its influence on clinical quinapril effectiveness in patients with arterial hypertension (AH) and obesity.Material and methods. Fifty AH patients - men and women aged 34-71 years (mean age 50,8+1,78 years) were examined. Physical examination, anthropometry, measurement of body mass index (BMI) and blood pressure (BP) by Korotkoff method, 24-hour BP monitoring (BMP) and visceral fat measurement with OMRON BF 302 device were performed.Results. In all participants, significant reduction in office BP (p<0,05), systolic BP (SBP) and pressure load area index (AI) for SBP by 24-hour BPM data (p<0,05) were observed. In participants with BW reduction, 16-week therapy was associated with reductions in office SBP (-20,29 %) and diastolic BP, DBP (-21,22 %), mean BP (-8,5 %), SBP and DBP by 24-hour BPM data (-7,43 % and-8,39 %, respectively; p<0,05), as well as in heart rate, HR (-8,2 %; p<0,05). Among those with BW reduction, SBP AI decreased by 51,13 %, DBP AI - by 38,93 %, SBP time index (TI) - by 37,9 %, and DBP TI - by 45,6 %. Circadian BP profile also changed.Conclusion. In participants without BW reduction, antihypertensive therapy was less effective than the combination of pharmaceutical and non-pharmaceutical treatment. Comparing to standard quinapril therapy, its combination with BW reduction was associated with better dynamics of 24-hour BPM results.

Keywords

• ожирение
• артериальная гипертензия
• немедикаментозная и медикаментозная терапия
• квинаприл
• снижение массы тела