SPECIFIC AND NONSPECIFIC IMMUNOREACTIVITY AT THE EXPERIMENTAL TUMOR PROCESS

Abstract

Immunization with xenogeneous tissue antigens is able to interrupt innate immune tolerance interfering immune response to autological analogues. The main part of the differentiation antigens is known to be normally expressed on the surface of numerous organs cells including testis. Thus, anticancer vaccine based on sheep testis spermatogenic epithelium lysed cells reveals notable protective effect in experiment. In this work we decided to investigate immunological aspects of the vaccination resulting in tumor mice lifetime increase. Following, testicular antigen vaccination of the tumor mice is established in addition to the lifetime increase to cause substantial helper and regulatory cells subpopulation increase to stimulate neutrophil release and to intensify tumor neutrophil infiltrate.

Keywords

• tumor
• vaccine
• memory cell
• neutrophil