PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

Theresa Bock; Clara Türk; Sriram Aravamudhan; Lena Keufgens; Wilhelm Bloch; Dieu Hien Rozsivalova; Vanina Romanello; Leonardo Nogara; Bert Blaauw; Aleksandra Trifunovic; Thomas Braun; Marcus Krüger

doi:10.1038/s41467-021-25185-3

Nature Communications (Aug 2021)

PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B

Theresa Bock,
Clara Türk,
Sriram Aravamudhan,
Lena Keufgens,
Wilhelm Bloch,
Dieu Hien Rozsivalova,
Vanina Romanello,
Leonardo Nogara,
Bert Blaauw,
Aleksandra Trifunovic,
Thomas Braun,
Marcus Krüger

Affiliations

Theresa Bock: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Clara Türk: BASF SE, Metabolomics and Proteomics
Sriram Aravamudhan: Cell Signaling Technology
Lena Keufgens: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Wilhelm Bloch: Department of Molecular and Cellular Sport Medicine, Institute of Sport Medicine and Cardiovascular Research, German Sport University Cologne
Dieu Hien Rozsivalova: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Vanina Romanello: Venetian Institute of Molecular Medicine (VIMM), Department of Biomedical Sciences Padova, University of Padova
Leonardo Nogara: Venetian Institute of Molecular Medicine (VIMM), Department of Biomedical Sciences Padova, University of Padova
Bert Blaauw: Venetian Institute of Molecular Medicine (VIMM), Department of Biomedical Sciences Padova, University of Padova
Aleksandra Trifunovic: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Thomas Braun: Max Planck Institute for Heart and Lung Research
Marcus Krüger: Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)

DOI: https://doi.org/10.1038/s41467-021-25185-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, suggesting PERM1 directs the mitochondria to the membrane.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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