A catalyst-free, green and efficient protocol for the synthesis of methyleneisoxazole-5(4H)-ones supported by ultrasonic irradiation
Jyothi Bankuru,
Venkateswara Rao Battula,
S. Tirumala Santhoshkumar,
Sidama Gopal,
Ram Pratap Meena,
N. Zaheer Ahmed
Affiliations
Jyothi Bankuru
Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India; Department of Chemistry, Maharajah's College(Autonomous), Vizianagaram, Andhra Pradesh, India
Venkateswara Rao Battula
Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India; Corresponding author.
S. Tirumala Santhoshkumar
Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu, India; Corresponding author.
Sidama Gopal
Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India; NRIUMSD, Hyderabad, India
Ram Pratap Meena
Central Council for Research Institute of Unani Medicine, Ministry of Ayush, GoI, New Delhi, India
N. Zaheer Ahmed
Central Council for Research Institute of Unani Medicine, Ministry of Ayush, GoI, New Delhi, India
A catalyst-free, green and efficient protocol for the one-pot, multi-component, synthesis of Methyleneisoxazole-5(4H)-ones (4a-l) from the reaction of Ethyl acetoacetate, aromatic aldehyde, and hydroxylamine hydrochloride in ethanol as green solvent under ultrasound irradiation at ambient temperature is described. This protocol offers several positive benefits, including simple handling, rapid reaction time period (≤10 mints), easy workup process, waste-free, gentler reaction conditions, ecologically friendly, cleaner reaction, absence of any a laborious purification and excellent yields.
