DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia

Eric M. Nickels; Shaobo Li; Swe Swe Myint; Katti Arroyo; Qianxi Feng; Kimberly D. Siegmund; Adam J. de Smith; Joseph L. Wiemels

doi:10.1038/s41467-022-33677-z

Nature Communications (Oct 2022)

DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia

Eric M. Nickels,
Shaobo Li,
Swe Swe Myint,
Katti Arroyo,
Qianxi Feng,
Kimberly D. Siegmund,
Adam J. de Smith,
Joseph L. Wiemels

Affiliations

Eric M. Nickels: Children’s Hospital Los Angeles, Cancer and Blood Disease Institute
Shaobo Li: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Swe Swe Myint: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Katti Arroyo: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Qianxi Feng: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Kimberly D. Siegmund: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Adam J. de Smith: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California
Joseph L. Wiemels: Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Norris Comprehensive Cancer Center, University of Southern California

DOI: https://doi.org/10.1038/s41467-022-33677-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

The role of DNA methylation in predisposing to pediatric acute lymphoblastic leukemia remains unknown. Here, the authors utilize a discordant twin model to investigate how DNA methylation variation contributes to disease risk in genetically identical subjects.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal