In Vitro Effects of Oestrogens, Antioestrogens and SERMs on Pancreatic Solid Pseudopapillary Neoplasm-Derived Primary Cell Culture

Isabella Tognarini; Francesco Tonelli; Gabriella Nesi; Valentina Martineti; Gianna Galli; Alessia Gozzini; Emanuela Colli; Roberto Zonefrati; Milena Paglierani; Francesca Marini; Sabina Sorace; Tiziana Cavalli; Loredana Cavalli; Annalisa Tanini; Maria Luisa Brandi

doi:10.3233/CLO-2010-0522

Cellular Oncology (Jan 2010)

In Vitro Effects of Oestrogens, Antioestrogens and SERMs on Pancreatic Solid Pseudopapillary Neoplasm-Derived Primary Cell Culture

Isabella Tognarini,
Francesco Tonelli,
Gabriella Nesi,
Valentina Martineti,
Gianna Galli,
Alessia Gozzini,
Emanuela Colli,
Roberto Zonefrati,
Milena Paglierani,
Francesca Marini,
Sabina Sorace,
Tiziana Cavalli,
Loredana Cavalli,
Annalisa Tanini,
Maria Luisa Brandi

Affiliations

Isabella Tognarini: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Francesco Tonelli: Department of Clinical Physiopathology, University of Florence Medical School, Florence, Italy
Gabriella Nesi: Department of Pathology, University of Florence Medical School, Florence, Italy
Valentina Martineti: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Gianna Galli: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Alessia Gozzini: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Emanuela Colli: Department of Clinical Physiopathology, University of Florence Medical School, Florence, Italy
Roberto Zonefrati: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Milena Paglierani: Department of Pathology, University of Florence Medical School, Florence, Italy
Francesca Marini: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Sabina Sorace: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Tiziana Cavalli: Department of Clinical Physiopathology, University of Florence Medical School, Florence, Italy
Loredana Cavalli: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Annalisa Tanini: Department of Internal Medicine, University of Florence Medical School, Florence, Italy
Maria Luisa Brandi: Department of Internal Medicine, University of Florence Medical School, Florence, Italy

DOI: https://doi.org/10.3233/CLO-2010-0522
Journal volume & issue: Vol. 32, no. 5-6
pp. 331 – 343

Abstract

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Background: Solid-pseudopapillary neoplasms of the pancreas (SPNs) are uncommon tumours usually frequent in young women. Although the pathogenesis of SPNs is uncertain a potential influence of the sex hormone milieu on the biology of these tumours has been suggested. The controversial expression of oestrogen receptors (ERs) in SPNs, provide a rationale for studying the effects of oestrogenic molecules on SPN development.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://www.hindawi.com/journals/acp/

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