Nature Communications (Apr 2018)
Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
- Zhengyan Kan,
- Ying Ding,
- Jinho Kim,
- Hae Hyun Jung,
- Woosung Chung,
- Samir Lal,
- Soonweng Cho,
- Julio Fernandez-Banet,
- Se Kyung Lee,
- Seok Won Kim,
- Jeong Eon Lee,
- Yoon-La Choi,
- Shibing Deng,
- Ji-Yeon Kim,
- Jin Seok Ahn,
- Ying Sha,
- Xinmeng Jasmine Mu,
- Jae-Yong Nam,
- Young-Hyuck Im,
- Soohyeon Lee,
- Woong-Yang Park,
- Seok Jin Nam,
- Yeon Hee Park
Affiliations
- Zhengyan Kan
- Pfizer Oncology Research
- Ying Ding
- Pfizer Oncology Research
- Jinho Kim
- Samsung Genome Institute, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Hae Hyun Jung
- Samsung Biological Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Woosung Chung
- Samsung Genome Institute, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Samir Lal
- Pfizer Oncology Research
- Soonweng Cho
- Pfizer Oncology Research
- Julio Fernandez-Banet
- Pfizer Oncology Research
- Se Kyung Lee
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Seok Won Kim
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jeong Eon Lee
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Yoon-La Choi
- Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Shibing Deng
- Pfizer Oncology Research
- Ji-Yeon Kim
- Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jin Seok Ahn
- Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Ying Sha
- Pfizer Oncology Research
- Xinmeng Jasmine Mu
- Pfizer Oncology Research
- Jae-Yong Nam
- Samsung Genome Institute, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Young-Hyuck Im
- Samsung Biological Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Soohyeon Lee
- Pfizer Oncology
- Woong-Yang Park
- Samsung Genome Institute, Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Seok Jin Nam
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Yeon Hee Park
- Samsung Biological Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04129-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
While breast cancer incidence in the Asia Pacific region is rising, the molecular basis remains poorly characterized. Here the authors perform genomic screening of 187 Korean breast cancer patients and find differences in molecular subtype distribution, mutation pattern and prevalence, and gene expression signature when compared to TCGA.
