Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism

Mohammad Zulkifli; John K. Neff; Shrishiv A. Timbalia; Natalie M. Garza; Yingqi Chen; Jeramie D. Watrous; Marta Murgia; Prachi P. Trivedi; Steven K. Anderson; Dhanendra Tomar; Roland Nilsson; Muniswamy Madesh; Mohit Jain; Vishal M. Gohil

doi:10.1038/s41467-020-18704-1

Nature Communications (Sep 2020)

Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism

Mohammad Zulkifli,
John K. Neff,
Shrishiv A. Timbalia,
Natalie M. Garza,
Yingqi Chen,
Jeramie D. Watrous,
Marta Murgia,
Prachi P. Trivedi,
Steven K. Anderson,
Dhanendra Tomar,
Roland Nilsson,
Muniswamy Madesh,
Mohit Jain,
Vishal M. Gohil

Affiliations

Mohammad Zulkifli: Department of Biochemistry and Biophysics, Texas A&M University
John K. Neff: Department of Biochemistry and Biophysics, Texas A&M University
Shrishiv A. Timbalia: Department of Biochemistry and Biophysics, Texas A&M University
Natalie M. Garza: Department of Biochemistry and Biophysics, Texas A&M University
Yingqi Chen: Departments of Medicine and Pharmacology, University of California, San Diego
Jeramie D. Watrous: Departments of Medicine and Pharmacology, University of California, San Diego
Marta Murgia: Department of Biomedical Sciences, University of Padova
Prachi P. Trivedi: Department of Biochemistry and Biophysics, Texas A&M University
Steven K. Anderson: Department of Biochemistry and Biophysics, Texas A&M University
Dhanendra Tomar: Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
Roland Nilsson: Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet
Muniswamy Madesh: Department of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health Science Center at San Antonio
Mohit Jain: Departments of Medicine and Pharmacology, University of California, San Diego
Vishal M. Gohil: Department of Biochemistry and Biophysics, Texas A&M University

DOI: https://doi.org/10.1038/s41467-020-18704-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

Although some fungal mitochondria lack the calcium uniporter, many intriguingly encode homologs of the uniporter assembly factor MCUR1. Here, the authors show that in budding yeast, the MCUR1 homologs Put6 and Put7 regulate mitochondrial proline metabolism, a function also conserved in human MCUR1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal