Nature Communications (Jan 2016)

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

  • Minako Imamura,
  • Atsushi Takahashi,
  • Toshimasa Yamauchi,
  • Kazuo Hara,
  • Kazuki Yasuda,
  • Niels Grarup,
  • Wei Zhao,
  • Xu Wang,
  • Alicia Huerta-Chagoya,
  • Cheng Hu,
  • Sanghoon Moon,
  • Jirong Long,
  • Soo Heon Kwak,
  • Asif Rasheed,
  • Richa Saxena,
  • Ronald C. W. Ma,
  • Yukinori Okada,
  • Minoru Iwata,
  • Jun Hosoe,
  • Nobuhiro Shojima,
  • Minaka Iwasaki,
  • Hayato Fujita,
  • Ken Suzuki,
  • John Danesh,
  • Torben Jørgensen,
  • Marit E. Jørgensen,
  • Daniel R. Witte,
  • Ivan Brandslund,
  • Cramer Christensen,
  • Torben Hansen,
  • Josep M. Mercader,
  • Jason Flannick,
  • Hortensia Moreno-Macías,
  • Noël P. Burtt,
  • Rong Zhang,
  • Young Jin Kim,
  • Wei Zheng,
  • Jai Rup Singh,
  • Claudia H. T. Tam,
  • Hiroshi Hirose,
  • Hiroshi Maegawa,
  • Chikako Ito,
  • Kohei Kaku,
  • Hirotaka Watada,
  • Yasushi Tanaka,
  • Kazuyuki Tobe,
  • Ryuzo Kawamori,
  • Michiaki Kubo,
  • Yoon Shin Cho,
  • Juliana C. N. Chan,
  • Dharambir Sanghera,
  • Philippe Frossard,
  • Kyong Soo Park,
  • Xiao-Ou Shu,
  • Bong-Jo Kim,
  • Jose C. Florez,
  • Teresa Tusié-Luna,
  • Weiping Jia,
  • E Shyong Tai,
  • Oluf Pedersen,
  • Danish Saleheen,
  • Shiro Maeda,
  • Takashi Kadowaki

DOI
https://doi.org/10.1038/ncomms10531
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.