Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Melissa R. Cruz; Shane Cristy; Shantanu Guha; Giuseppe Buda De Cesare; Elena Evdokimova; Hiram Sanchez; Dominika Borek; Pedro Miramón; Junko Yano; Paul L. Fidel; Alexei Savchenko; David R. Andes; Peter J. Stogios; Michael C. Lorenz; Danielle A. Garsin

doi:10.1038/s41467-022-33613-1

Nature Communications (Oct 2022)

Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Melissa R. Cruz,
Shane Cristy,
Shantanu Guha,
Giuseppe Buda De Cesare,
Elena Evdokimova,
Hiram Sanchez,
Dominika Borek,
Pedro Miramón,
Junko Yano,
Paul L. Fidel,
Alexei Savchenko,
David R. Andes,
Peter J. Stogios,
Michael C. Lorenz,
Danielle A. Garsin

Affiliations

Melissa R. Cruz: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Shane Cristy: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Shantanu Guha: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Giuseppe Buda De Cesare: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Elena Evdokimova: BioZone, Department of Chemical Engineering and Applied Chemistry, University of Toronto
Hiram Sanchez: Department of Medicine, University of Wisconsin
Dominika Borek: Department of Biophysics, The University of Texas Southwestern Medical Center
Pedro Miramón: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Junko Yano: Department of Oral and Craniofacial Biology, Louisiana State University Health School of Dentistry
Paul L. Fidel: Department of Oral and Craniofacial Biology, Louisiana State University Health School of Dentistry
Alexei Savchenko: BioZone, Department of Chemical Engineering and Applied Chemistry, University of Toronto
David R. Andes: Department of Medicine, University of Wisconsin
Peter J. Stogios: BioZone, Department of Chemical Engineering and Applied Chemistry, University of Toronto
Michael C. Lorenz: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston
Danielle A. Garsin: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/s41467-022-33613-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Enterococcus faecalis has been reported to inhibit Candida albicans virulence via secretion of the bacteriocin EntV. Here, the authors present the crystal structure and characterise the antifungal properties of this peptide in numerous in vitro and in vivo assays.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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