Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta (Mar 2020)

CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION

  • Zybleva S. V.,
  • Zyblev S. L.

DOI
https://doi.org/10.25298/2221-8785-2020-18-1-17-20
Journal volume & issue
Vol. 18, no. 1
pp. 17 – 20

Abstract

Read online

Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection. Objective. To study the indices of CD3+CD4+CD8+ double- positive T-lymphocytes before kidney transplantation in patients with early allograft dysfunction. Material and Methods. We examined 199 recipients who underwent kidney transplantation. CD3+CD4+CD8+ count was determined before transplantation. All the patients were divided into 2 groups: those with primary graft function (PGF) and those with graft dysfunction (PGD). A correlation analysis was performed between the values of CD3+CD4+CD8+ and the biomarkers indices of allograft function on the 7th day. Results. Before transplantation the CD3+CD4+CD8+ count was significantly lower in recipients with early allograft dysfunction as compared to the group with primary allograft function. The CD3+CD4+CD8+ indices were determined to predict the development of early allograft dysfunction. Conclusions. The CD3+CD4+CD8+ indices in recipients before kidney transplantation can be used to predict the development of early allograft dysfunction.

Keywords