LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson’s Disease Patients with Wearing Off: A Prospective, Open-Label Study

Tatsuya Ueno; Megumi Sasaki; Haruo Nishijima; Yukihisa Funamizu; Tomoya Kon; Rie Haga; Akira Arai; Chieko Suzuki; Jin-ichi Nunomura; Masayuki Baba; Masahiko Tomiyama

doi:10.1155/2017/8130140

Parkinson's Disease (Jan 2017)

LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson’s Disease Patients with Wearing Off: A Prospective, Open-Label Study

Tatsuya Ueno,
Megumi Sasaki,
Haruo Nishijima,
Yukihisa Funamizu,
Tomoya Kon,
Rie Haga,
Akira Arai,
Chieko Suzuki,
Jin-ichi Nunomura,
Masayuki Baba,
Masahiko Tomiyama

Affiliations

Tatsuya Ueno: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Megumi Sasaki: Department of Rehabilitation, Aomori Prefectural Central Hospital, Aomori, Japan
Haruo Nishijima: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Yukihisa Funamizu: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Tomoya Kon: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Rie Haga: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Akira Arai: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Chieko Suzuki: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Jin-ichi Nunomura: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Masayuki Baba: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
Masahiko Tomiyama: Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan

DOI: https://doi.org/10.1155/2017/8130140
Journal volume & issue: Vol. 2017

Abstract

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The efficacy of LSVT-BIG for advanced Parkinson’s disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson’s Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the “on” time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the “off” state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.

Published in Parkinson's Disease

ISSN: 2090-8083 (Print); 2042-0080 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://onlinelibrary.wiley.com/journal/1618

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